Negoita, M;
Hughes, AD;
Parker, KH;
Khir, AW;
(2017)
Non-invasive technique for determining local pulse wave velocity in humans ascending aorta.
In: Murray, Alan, (ed.)
Proceedings of the Computing in Cardiology (CinC) - 2017.
Universite De Rennes: Rennes, France.
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Abstract
Background: Pulse wave velocity (PWV) is a measure of arterial stiffness and widely used as a predictor of cardiovascular risk. Local PWV (lPWV) can be calculated non-invasively using the ln(D)U-loop method. Aim: To develop a novel non-invasive technique for the determination of lPWV in human ascending aorta. Methods: 13 healthy volunteers (19-33 years, 6 females) were studied using ultrasound (GE, Vivid E95) with a 1.5–4.5 MHz phased array transducer. M-mode in the parasternal long axis view was used for diameter measurements, Pulsed Wave Doppler ultrasound in the apical 5 chamber view was used for blood velocity measurements in the ascending aorta. Diameter and flow were measured sequentially. The ln(D)U-loop method was used to determine lPWV, and the SphygmoCor Xcel (AtCor Medical, Australia) was used to measure carotid-femoral PWV (cfPWV). Results: Mean lPWV using ln(D)U-loop was 3.6±0.7 m/s with higher values for men compared to women. The results showed that lPWV was systematically lower than cfPWV. Conclusions: lPWV can be measured non-invasively at the ascending aorta by ultrasound with sequential recordings of diameter and velocity using the ln(D)Uloop method.
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