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Organ preservation solutions: linking pharmacology to survival for the donor organ pathway

Fuller, B; Froghi, F; Davidson, B; (2018) Organ preservation solutions: linking pharmacology to survival for the donor organ pathway. Current Opinion in Organ Transplantation , 23 (3) pp. 361-368. 10.1097/MOT.0000000000000525. Green open access

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Abstract

PURPOSE OF REVIEW: To provide an understanding of the scientific principles, which underpinned the development of organ preservation solutions, and to bring into context new strategies and challenges for solution development against the background of changing preservation technologies and expanded criteria donor access. RECENT FINDINGS: Improvements in organ preservation solutions continue to be made with new pharmacological approaches. New solutions have been developed for dynamic perfusion preservation and are now in clinical application. Principles defining organ preservation solution pharmacology are being applied for cold chain logistics in tissue engineering and regenerative medicine. SUMMARY: Organ preservation solutions support the donor organ pathway. The solution compositions allow additives and pharmacological agents to be delivered direct to the target organ to mitigate preservation injury. Changing preservation strategies provide further challenges and opportunities to improve organ preservation solutions.

Type: Article
Title: Organ preservation solutions: linking pharmacology to survival for the donor organ pathway
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/MOT.0000000000000525
Publisher version: https://doi.org/10.1097/MOT.0000000000000525
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10048162
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