Town, K;
Bolt, H;
Croxford, S;
Cole, M;
Harris, S;
Field, N;
Hughes, G;
(2018)
Neisseria gonorrhoeae molecular typing for understanding sexual networks and antimicrobial resistance transmission: a systematic review.
Journal of Infection
, 76
(6)
pp. 507-514.
10.1016/j.jinf.2018.02.011.
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Abstract
OBJECTIVES: Neisseria gonorrhoeae (NG) is a significant global public health concern due to rising diagnoses rates and antimicrobial resistance. Molecular combined with epidemiological data have been used to understand the distribution and spread of NG, as well as relationships between cases in sexual networks, but the public health value gained from these studies is unclear. We conducted a systematic review to examine how molecular epidemiological studies have informed understanding of sexual networks and NG transmission, and subsequent public health interventions. METHODS: Five research databases were systematically searched up to 31st March 2017 for studies that used sequence-based DNA typing methods, including whole genome sequencing, and linked molecular data to patient-level epidemiological data. Data were extracted and summarised to identify common themes. RESULTS: Of the 49 studies included, 82% used NG Multi-antigen Sequence Typing. Gender and sexual orientation were commonly used to characterise sexual networks that were inferred using molecular clusters; clusters predominantly of one patient group often contained a small number of isolates from other patient groups. Suggested public health applications included using these data to target interventions at specific populations, confirm outbreaks, and inform partner management, but these were mainly untested. CONCLUSIONS: Combining molecular and epidemiological data has provided insight into sexual mixing patterns, and dissemination of NG, but few studies have applied these findings to design or evaluate public health interventions. Future studies should focus on the application of molecular epidemiology in public health practice to provide evidence for how to prevent and control NG.
| Type: | Article |
|---|---|
| Title: | Neisseria gonorrhoeae molecular typing for understanding sexual networks and antimicrobial resistance transmission: a systematic review |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jinf.2018.02.011 |
| Publisher version: | http://doi.org/10.1016/j.jinf.2018.02.011 |
| Language: | English |
| Additional information: | © 2018 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Neisseria gonorrhoeae, Sexually transmitted infection, Gonorrhoea, Molecular epidemiology, Molecular typing, Whole genome sequencing, Neisseria Gonorrhoeae Multi-Antigen, Sequence Typing, Multi-Locus Sequence Typing, Public health, Sexual health |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047884 |
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