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Positioning Europe for the EPITRANSCRIPTOMICS challenge

Jantsch, M; Quattrone, A; O'Connell, M; Helm, M; Frye, M; Macias-Gonzales, M; Ohman, M; ... Fray, R; + view all (2018) Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA Biology , 15 (6) pp. 829-831. 10.1080/15476286.2018.1460996. Green open access

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Abstract

The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease.

Type: Article
Title: Positioning Europe for the EPITRANSCRIPTOMICS challenge
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/15476286.2018.1460996
Publisher version: http://dx.doi.org/10.1080/15476286.2018.1460996
Language: English
Additional information: Copyright © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
Keywords: Database of Modification, Detection of RNA modification, Epitranscriptomics, European funding, Model Systems
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10047787
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