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Molecular profiling of colorectal pulmonary metastases and primary tumours: implications for targeted treatment

Moorcraft, SY; Jones, T; Walker, BA; Ladas, G; Kalaitzaki, E; Yuan, L; Begum, R; ... Chau, I; + view all (2017) Molecular profiling of colorectal pulmonary metastases and primary tumours: implications for targeted treatment. Oncotarget , 8 (39) pp. 64999-65008. 10.18632/oncotarget.17048. Green open access

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Abstract

This study aimed to molecularly characterise colorectal pulmonary metastases (PM) and investigate whether their molecular profiles were concordant with those of the primary tumour. Clinical data and archival formalin fixed paraffin embedded tissue samples were retrospectively collected from patients who underwent ≥ 1 pulmonary metastasectomies for colorectal cancer between 1997–2012. Primary tumour and metastatic samples were analysed using a targeted capture sequencing panel of 46 cancer-associated genes. The 5-year progression-free and overall survival rates for the 81 patients in this study were 32% (95% CI 22–42%) and 77% (95% CI 66–85%) respectively. Fifty-four patients had samples available from ≥ 1 PM, and sequencing data were successfully obtained from 33 PM from 24 patients. The most frequently mutated genes were APC (71%), KRAS (58%) and TP53 (46%). Seventy-three percent of the 15 patients with matched primary and PM samples and 6 of the 7 patients (86%) with data from ≥ 2 PM had concordant molecular profiles. The concordance for KRAS and NRAS was 100%. At our institutions, patients with resectable colorectal PM had a favourable prognosis. RAS mutations were commonly detected in PM and the molecular profiles of colorectal PM were highly concordant with the primary tumour.

Type: Article
Title: Molecular profiling of colorectal pulmonary metastases and primary tumours: implications for targeted treatment
Open access status: An open access version is available from UCL Discovery
DOI: 10.18632/oncotarget.17048
Publisher version: https://doi.org/10.18632/oncotarget.17048
Language: English
Additional information: © 2017 Moorcraft et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (https://creativecommons.org/licenses/by/3.0/).
Keywords: colorectal cancer, heterogeneity, metastasectomy, pulmonary metastases, RAS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10047784
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