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Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

Dixon-Suen, SC; Nagle, CM; Thrift, AP; Pharoah, PDP; Ewing, A; Pearce, CL; Zheng, W; ... Ovarian Cancer Association Consortium; + view all (2018) Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. Br J Cancer , 118 (8) pp. 1123-1129. 10.1038/s41416-018-0011-3. Green open access

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Abstract

BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

Type: Article
Title: Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41416-018-0011-3
Publisher version: http://dx.doi.org/10.1038/s41416-018-0011-3
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cancer epidemiology, Genetics research, Ovarian cancer, Risk factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10047755
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