UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The role of transvaginal ultrasound in screening for ovarian cancer

Campbell, S; Gentry-Maharaj, A; (2018) The role of transvaginal ultrasound in screening for ovarian cancer. Climacteric , 21 (3) pp. 221-226. 10.1080/13697137.2018.1433656. Green open access

[thumbnail of Climacteric_Screening for OC_Campbell_Gentry-Maharaj_Uploaded.pdf]
Preview
Text
Climacteric_Screening for OC_Campbell_Gentry-Maharaj_Uploaded.pdf - Accepted Version

Download (507kB) | Preview

Abstract

Ovarian cancer is a low-prevalence postmenopausal cancer with a high mortality rate and is the fifth most lethal cancer in women. The most common serous subtype with TP53 mutations spreads rapidly throughout the peritoneal cavity (stage III/IV) when 5-year survival is 10%. If diagnosed while confined to the ovary (stage I), the survival rate exceeds 90%. This is the rationale for screening. Annual transvaginal ultrasound (TVU) scans used as a primary screening modality or as a second-line test following primary screening with serum CA125 (multimodal) have been investigated in several trials. Only two large randomized controlled trials have provided mortality data. The US Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial studied over 78 000 women (randomized to screening with either TVU or CA125, or control) over 6 years with 14 years follow-up and found no mortality benefit from screening and increased morbidity in the screened arm. The UK Collaborative Trial of Ovarian Cancer Screening studied over 202 000 women randomized to TVU, multimodal or control in a 1 : 1 : 2 ratio over 7-11 years with 11 years follow-up. CA125 was interpreted by the Risk of Ovarian Cancer algorithm which identifies a rise in the level rather than a fixed cut-off. There was a late reduction in mortality after 7 years in the screened arm (23% in the multimodal arm and 21% in the TVU arm), but the overall reduction was not significant. Further follow-up may reveal whether TVU has a primary or secondary role in ovarian cancer screening.

Type: Article
Title: The role of transvaginal ultrasound in screening for ovarian cancer
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/13697137.2018.1433656
Publisher version: https://doi.org/10.1080/13697137.2018.1433656
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CA125, Ovarian cancer, ROC algorithm, UKCTOCS, randomized controlled trials, screening, transvaginal ultrasound
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10047731
Downloads since deposit
433Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item