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Enteric Neural Stem Cell Therapies for Enteric Neuropathies

McCann, C; Thapar, N; (2018) Enteric Neural Stem Cell Therapies for Enteric Neuropathies. Neurogastroenterology and Motility , 30 (10) , Article e13369. 10.1111/nmo.13369. Green open access

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Abstract

BACKGROUND: Enteric neuropathies exist as a wide range of human disorders which impact on gastrointestinal motility. Current standard therapies for enteric neuropathies are limited to surgical resection or manipulation (eg, myotomy) of affected gut segments or medical management including both therapy (eg, prokinetic pharmacotherapy) and support such as parenteral nutrition. However, such treatments often result in poor prognosis and significant morbidity. The current limitations in treatment options for enteric neuropathies underline the need for alternative approaches to treat these devastating diseases. Recent advances have highlighted the potential of enteric neural stem cells as a possible treatment option for regenerative medicine, in such cases. // PURPOSE: The purpose of this review is to provide an up‐to‐date synopsis of the enteric neural stem cell research field. Here, we review in detail the initial characterization of enteric neural stem cells, early preclinical studies validating their use in murine models through to the most recent findings of therapeutic rescue of diseased gut tissue. We additionally pose a number of questions regarding these recent findings which will need to be addressed prior to clinical translation of this exciting cellular therapeutic.

Type: Article
Title: Enteric Neural Stem Cell Therapies for Enteric Neuropathies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nmo.13369
Publisher version: http://dx.doi.org/10.1111/nmo.13369
Language: English
Additional information: © 2018 The Authors. Neurogastroenterology & Motility Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: enteric nervous system, enteric neural stem cell, enteric neuropathy, stem cell transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10047652
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