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Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex

Dipoppa, M; Ranson, A; Krumin, M; Pachitariu, M; Carandini, M; Harris, KD; (2018) Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex. Neuron , 98 (3) 602-615.e8. 10.1016/j.neuron.2018.03.037. Green open access

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Abstract

Cortical computation arises from the interaction of multiple neuronal types, including pyramidal (Pyr) cells and interneurons expressing Sst, Vip, or Pvalb. To study the circuit underlying such interactions, we imaged these four types of cells in mouse primary visual cortex (V1). Our recordings in darkness were consistent with a "disinhibitory" model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli. A recurrent network model successfully predicted each cell type's activity from the measured activity of other types. Capturing the effects of locomotion, however, required allowing it to increase feedforward synaptic weights and modulate recurrent weights. This network model summarizes interneuron interactions and suggests that locomotion may alter cortical computation by changing effective synaptic connectivity.

Type: Article
Title: Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2018.03.037
Publisher version: https://doi.org/10.1016/j.neuron.2018.03.037
Language: English
Additional information: © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Circuit, disinhibition, inhibition, inhibition stabilized network, interneurons, locomotion, neural field model, primary visual cortex, recurrence, surround suppression
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10047619
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