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Neural mediators of changes of mind about perceptual decisions

Fleming, SM; van der Putten, EJ; Daw, ND; (2018) Neural mediators of changes of mind about perceptual decisions. Nature Neuroscience , 21 (4) pp. 617-624. 10.1038/s41593-018-0104-6. Green open access

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Abstract

Changing one's mind on the basis of new evidence is a hallmark of cognitive flexibility. To revise our confidence in a previous decision, we should use new evidence to update beliefs about choice accuracy. How this process unfolds in the human brain, however, remains unknown. Here we manipulated whether additional sensory evidence supports or negates a previous motion direction discrimination judgment while recording markers of neural activity in the human brain using fMRI. A signature of post-decision evidence (change in log-odds correct) was selectively observed in the activity of posterior medial frontal cortex. In contrast, distinct activity profiles in anterior prefrontal cortex mediated the impact of post-decision evidence on subjective confidence, independently of changes in decision value. Together our findings reveal candidate neural mediators of post-decisional changes of mind in the human brain and indicate possible targets for ameliorating deficits in cognitive flexibility.

Type: Article
Title: Neural mediators of changes of mind about perceptual decisions
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-018-0104-6
Publisher version: http://dx.doi.org/10.1038/s41593-018-0104-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10047600
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