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Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Morrison, JL; Botting, KJ; Darby, JRT; David, AL; Dyson, RM; Gatford, KL; Gray, C; ... Berry, MJ; + view all (2018) Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. Journal of Physiology , 596 (23) pp. 5535-5569. 10.1113/JP274948. Green open access

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Abstract

Over 30 years ago Sir David Barker first proposed the theory that events in early life could explain an individuals' risk of non-communicable disease in later life; the Developmental Origins of Health and Disease (DOHaD) theory. During the 1990s the validity of the DOHaD theory was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, their strengths and limitations as an experimental model of DOHaD and their potential to enhance clinical therapeutic innovation to improve human health. This article is protected by copyright. All rights reserved.

Type: Article
Title: Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1113/JP274948
Publisher version: http://dx.doi.org/10.1113/JP274948
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: DOHaD, guinea pig, animal models, fetus, placenta, pregnancy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10047579
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