Pichaud, F;
(2018)
PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.
Frontiers in Cellular Neuroscience
, 12
, Article 90. 10.3389/fncel.2018.00090.
Preview |
Text
fncel-12-00090.pdf - Published Version Download (2MB) | Preview |
Abstract
The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA), thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.
| Type: | Article |
|---|---|
| Title: | PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fncel.2018.00090 |
| Publisher version: | http://doi.org/10.3389/fncel.2018.00090 |
| Language: | English |
| Additional information: | © 2018 Pichaud. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, cell polarity, epithelial cells, sensory neurons, retina, Crumbs complex, PAR complex, Drosophila melanogaster, neuroepithelial cells, DROSOPHILA EPITHELIAL-CELLS, ADHERENS JUNCTIONS, NEUROEPITHELIAL CELLS, SPONTANEOUS EMERGENCE, APICAL MEMBRANE, TIGHT JUNCTIONS, PROTEIN CRUMBS, COMPOUND EYE, DE-CADHERIN, POLARITY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047316 |
Archive Staff Only
 |
View Item |
