Sia, DIT;
Thaung, C;
O'Hanlon-Brown, C;
Cohen, VML;
Sagoo, MS;
(2018)
Immune privilege: failure of immunotherapy in controlling metastatic cutaneous melanoma to the eye.
Melanoma Research
, 28
(4)
pp. 359-362.
10.1097/CMR.0000000000000443.
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Abstract
This report concerns a 49-year-old female with cutaneous malignant melanoma and systemic metastases. These resolved following combination immunotherapy with ipilimumab and nivolumab. She subsequently experienced unilateral floaters, an increase in iris pigmentation and pigmentary glaucoma. The eye progressively lost vision and became painful due to iris neovascularization. The clinical diagnosis was of cutaneous melanoma metastatic to the vitreous, ciliary body and iris. Enucleation was performed for symptom control, with histopathology confirming the clinical diagnosis. The immune privilege of the eye may preclude ocular metastasis control with immunotherapy. Ocular symptoms in such patients merit referral to an ophthalmologist.
| Type: | Article |
|---|---|
| Title: | Immune privilege: failure of immunotherapy in controlling metastatic cutaneous melanoma to the eye |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/CMR.0000000000000443 |
| Publisher version: | http://dx.doi.org/10.1097/CMR.0000000000000443 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | metastatic cutaneous melanoma, melanoma, ocular metastasis, immunotherapy, immune privilege |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047250 |
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