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Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy

Sagar, R; Walther-Jallow, L; David, AL; Götherström, C; Westgren, M; (2018) Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy. Current Stem Cell Reports , 4 (1) pp. 61-68. 10.1007/s40778-018-0118-8. Green open access

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Abstract

PURPOSE OF REVIEW: The aim of the study is to provide an overview on the possibility of treating congenital disorders prenatally with mesenchymal stromal cells (MSCs). RECENT FINDINGS: MSCs have multilineage potential and a low immunogenic profile and are immunomodulatory and more easy to expand in culture. Their ability to migrate, engraft and differentiate, or act via a paracrine effect on target tissues makes MSCs candidates for clinical therapies. Fetal and extra-fetal MSCs offer higher therapeutic potential compared to MSCs derived from adult sources. SUMMARY: MSCs may be safely transplanted prenatally via ultrasound-guided injection into the umbilical cord. Due to these characteristics, fetal MSCs are of great interest in the field of in utero stem cell transplantation for treatment of congenital disease.

Type: Article
Title: Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40778-018-0118-8
Publisher version: https://doi.org/10.1007/s40778-018-0118-8
Language: English
Additional information: Copyright © The Author(s) 2018. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: In utero stem cell transplantation, Mesenchymal stromal cells, Prenatal therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10046955
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