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Electrically tunable fluidic lens imaging system for laparoscopic fluorescence-guided surgery

Volpi, D; Tullis, IDC; Barber, PR; Augustyniak, EM; Smart, SC; Vallis, KA; Vojnovic, B; (2017) Electrically tunable fluidic lens imaging system for laparoscopic fluorescence-guided surgery. Biomedical Optics Express , 8 (7) pp. 3232-3247. 10.1364/BOE.8.003232. Green open access

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Abstract

The addition of fluorescence guidance in laparoscopic procedures has gained significant interest in recent years, particularly through the use of near infrared (NIR) markers. In this work we present a novel laparoscope camera coupler based on an electrically tunable fluidic lens that permits programmable focus control and has desirable achromatic performance from the visible to the NIR. Its use extends the lower working distance limit and improves detection sensitivity, important for work with molecularly targeted fluorescence markers. We demonstrate its superior optical performance in laparoscopic fluorescence-guided surgery. In vivo results using a tumor specific molecular probe and a nonspecific NIR dye are presented.

Type: Article
Title: Electrically tunable fluidic lens imaging system for laparoscopic fluorescence-guided surgery
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/BOE.8.003232
Publisher version: http://doi.org/10.1364/BOE.8.003232
Language: English
Additional information: Copyright © 2017 Optical Society of America. This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10046919
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