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Ins and outs of Ca2+ transport by acidic organelles and cell migration

Patel, S; (2018) Ins and outs of Ca2+ transport by acidic organelles and cell migration. Communicative and Integrative Biology , 11 (1) , Article e1331800. 10.1080/19420889.2017.1331800. Green open access

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Abstract

Much contemporary evidence underscores the pathophysiological importance of Ca2+ handling by acidic organelles such as lysosomes. Whereas our knowledge of how Ca2+ is released from these acidic Ca2+ stores (the ‘outs’) is advancing, we know relatively little about how Ca2+ uptake is effected (the ‘ins’). Here I highlight new work identifying animal Ca2+/H+ (CAX) exchangers that localize to acidic organelles, mediate Ca2+ uptake and regulate cell migration in vivo. Continued molecular definition of the acidic Ca2+ store toolkit provides new insight into Ca2+-dependent function.

Type: Article
Title: Ins and outs of Ca2+ transport by acidic organelles and cell migration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/19420889.2017.1331800
Publisher version: https://doi.org/10.1080/19420889.2017.1331800
Language: English
Additional information: © 2018 The Author. Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/ 4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way
Keywords: Two-pore channels, Acidic Ca2+ stores, CAX, cell migration, lysosomes, NAADP, neural crest
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10046800
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