Patel, S;
(2018)
Ins and outs of Ca2+ transport by acidic organelles and cell migration.
Communicative and Integrative Biology
, 11
(1)
, Article e1331800. 10.1080/19420889.2017.1331800.
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Abstract
Much contemporary evidence underscores the pathophysiological importance of Ca2+ handling by acidic organelles such as lysosomes. Whereas our knowledge of how Ca2+ is released from these acidic Ca2+ stores (the ‘outs’) is advancing, we know relatively little about how Ca2+ uptake is effected (the ‘ins’). Here I highlight new work identifying animal Ca2+/H+ (CAX) exchangers that localize to acidic organelles, mediate Ca2+ uptake and regulate cell migration in vivo. Continued molecular definition of the acidic Ca2+ store toolkit provides new insight into Ca2+-dependent function.
| Type: | Article |
|---|---|
| Title: | Ins and outs of Ca2+ transport by acidic organelles and cell migration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/19420889.2017.1331800 |
| Publisher version: | https://doi.org/10.1080/19420889.2017.1331800 |
| Language: | English |
| Additional information: | © 2018 The Author. Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/ 4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way |
| Keywords: | Two-pore channels, Acidic Ca2+ stores, CAX, cell migration, lysosomes, NAADP, neural crest |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10046800 |
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