Lachmandas, E;
Rios-Miguel, AB;
Koeken, VACM;
van der Pasch, E;
Kumar, V;
Matzaraki, V;
Li, Y;
... Pollara, G; + view all
(2018)
Tissue metabolic changes drive cytokine responses to Mycobacterium tuberculosis.
The Journal of Infectious Diseases
, 218
(1)
pp. 165-170.
10.1093/infdis/jiy173.
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Abstract
Cellular metabolism can influence host immune responses to Mycobacterium tuberculosis (Mtb). Using a systems biology approach, differential expression of 292 metabolic genes involved in glycolysis, glutathione, pyrimidine and inositol phosphate pathways was evident at the site of a human tuberculin skin test challenge in patients with active tuberculosis infection. For 28 metabolic genes, we identified single nucleotide polymorphisms (SNPs) that were trans-acting for in vitro cytokine responses to Mtb stimulation, including glutathione and pyrimidine metabolism genes that alter production of Th1 and Th17 cytokines. Our findings identify novel therapeutic targets in host metabolism that may shape protective immunity to tuberculosis.
| Type: | Article |
|---|---|
| Title: | Tissue metabolic changes drive cytokine responses to Mycobacterium tuberculosis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/infdis/jiy173 |
| Publisher version: | http://dx.doi.org/10.1093/infdis/jiy173 |
| Language: | English |
| Additional information: | © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | cytokine metabolism immune response glutathione genes glycolysis immunity inositol phosphates mycobacterium tuberculosis single nucleotide polymorphism pyrimidines tuberculin test tuberculosis infection metabolic disturbance pyrimidine metabolism pathway systems biology host (organism) active tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10046713 |
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