ten Kate, M;
Visser, PJ;
Bakardjian, H;
Barkhof, F;
Sikkes, SAM;
van der Flier, WM;
Scheltens, P;
... INSIGHT-preAD study group, .; + view all
(2018)
Gray Matter Network Disruptions and Regional Amyloid Beta in Cognitively Normal Adults.
Frontiers in Aging Neuroscience
, 10
, Article 67. 10.3389/fnagi.2018.00067.
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Abstract
The accumulation of amyloid plaques is one of the earliest pathological changes in Alzheimer’s disease (AD) and may occur 20 years before the onset of symptoms. Examining associations between amyloid pathology and other early brain changes is critical for understanding the pathophysiological underpinnings of AD. Alterations in gray matter networks might already start at early preclinical stages of AD. In this study, we examined the regional relationship between amyloid aggregation measured with positron emission tomography (PET) and gray matter network measures in elderly subjects with subjective memory complaints. Single-subject gray matter networks were extracted from T1-weigthed structural MRI in cognitively normal subjects (n = 318, mean age 76.1 ± 3.5, 64% female, 28% amyloid positive). Degree, clustering, path length and small world properties were computed. Global and regional amyloid load was determined using [18F]-Florbetapir PET. Associations between standardized uptake value ratio (SUVr) values and network measures were examined using linear regression models. We found that higher global SUVr was associated with lower clustering (β = −0.12, p < 0.05), and small world values (β = −0.16, p < 0.01). Associations were most prominent in orbito- and dorsolateral frontal and parieto-occipital regions. Local SUVr values showed less anatomical variability and did not convey additional information beyond global amyloid burden. In conclusion, we found that in cognitively normal elderly subjects, increased global amyloid pathology is associated with alterations in gray matter networks that are indicative of incipient network breakdown towards AD dementia.
| Type: | Article |
|---|---|
| Title: | Gray Matter Network Disruptions and Regional Amyloid Beta in Cognitively Normal Adults |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2018.00067 |
| Publisher version: | https://doi.org/10.3389/fnagi.2018.00067 |
| Language: | English |
| Additional information: | Copyright © 2018 The authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | amyloid beta, PET, gray matter network, graph theory, MRI, subjective memory complaints, Alzheimer’s disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10046707 |
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