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Designer fibers from 2D to 3D-Simultaneous and controlled engineering of morphology, shape and size

Yao, Z-C; Zhang, C; Ahmad, Z; Huang, J; Li, J-S; Chang, M-W; (2018) Designer fibers from 2D to 3D-Simultaneous and controlled engineering of morphology, shape and size. Chemical Engineering Journal , 334 pp. 89-98. 10.1016/j.cej.2017.10.033. Green open access

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Abstract

Topography and surface morphology of micrometer and nanometer scaled fibrous biomaterials are crucial for bioactive component encapsulation, release, promoting cell proliferation and interaction within biological environment. Specifically, for drug delivery and tissue repair applications, surface engineering provides control on both aspects in tandem. In this study, the bioactive component (ganoderma lucidum spore polysaccharide (GLSP)) was loaded into zein prolamine (ZP) fiber matrices via coaxial electrospinning (CES) technique. During the CES process, various outer layer enveloping fluids were used to modulate fiber topography in-situ (from 2D to 3D). SEM and water contact angle tests indicate enveloping media impact electrospun fiber diameter (ranging from 400 nm to 3.0 μm) and morphologies (from flat ribbon-like to solid cylindrical structures), with the latter impacting GLSP release profile. Furthermore, CCK-8 assay assessment indicates fibroblast cell proliferation (L929 cell line), while cell extension was also observed for modified ZP fibers. The results demonstrate potential applications of modified fiber morphologies, which are tailored in-situ without impacting chemical stability and encapsulation.

Type: Article
Title: Designer fibers from 2D to 3D-Simultaneous and controlled engineering of morphology, shape and size
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cej.2017.10.033
Publisher version: https://doi.org/10.1016/j.cej.2017.10.033
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Technology, Engineering, Environmental, Engineering, Chemical, Engineering, Fiber morphology, Zein prolamine, Coaxial electrospinning, Ganoderma lucidum spore polysaccharide, Biocompatibility, GANODERMA-LUCIDUM POLYSACCHARIDES, DRUG-RELEASE, NANOFIBER MEMBRANES, AQUEOUS-SOLUTIONS, COMPOSITE FIBERS, ESSENTIAL OIL, FISH-OIL, ZEIN, ENCAPSULATION, ANTIOXIDANT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10046599
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