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The emerging role of anti-CD25 directed therapies as both immune modulators and targeted agents in cancer

Flynn, MJ; Hartley, JA; (2017) The emerging role of anti-CD25 directed therapies as both immune modulators and targeted agents in cancer. [Review]. British Journal of Haematology , 179 (1) pp. 20-35. 10.1111/bjh.14770. Green open access

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Abstract

CD25 (also termed IL2RA) forms one component of the high‐affinity heterotrimeric interleukin 2 (IL2) receptor on activated T cells. Its affinity for IL2 and cellular function are tightly regulated and vary in different cell types. The high frequency of CD25 on the surface of many different haematological tumour cells is now well established and, apart from its prognostic significance, CD25 may be present on leukaemic stem cells and enable oncogenic signalling pathways in leukaemic cells. Additionally, high CD25 expression in activated circulating immune cells and Tregs is a factor that has already been exploited by IL2 immunotherapies for treatment of tumours and autoimmune disease. The relative clinical safety and efficacy of administering anti‐CD25 radioimmunoconjugates and immunotoxins in various haematological tumour indications has been established and clinical trials of a novel CD25‐directed antibody drug conjugate are underway.

Type: Article
Title: The emerging role of anti-CD25 directed therapies as both immune modulators and targeted agents in cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bjh.14770
Publisher version: http://doi.org/10.1111/bjh.14770
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10046564
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