UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

McGranahan, N; Swanton, C; (2017) Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future. Cell , 168 (4) pp. 613-628. 10.1016/j.cell.2017.01.018. Green open access

[img]
Preview
Text
McGranahan_CellReviewResubmission_final.pdf - Accepted version

Download (369kB) | Preview

Abstract

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have revealed intra-tumor heterogeneity across cancer types and the dynamics, constraints, and contingencies inherent to tumor evolution. We emphasize the importance of macro-evolutionary leaps, often involving large-scale chromosomal alterations, in driving tumor evolution and metastasis and consider the role of the tumor microenvironment in engendering heterogeneity and drug resistance. We suggest that bold approaches to drug development, harnessing the adaptive properties of the immune-microenvironment while limiting those of the tumor, combined with advances in clinical trial-design, will improve patient outcome.

Type: Article
Title: Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2017.01.018
Publisher version: http://dx.doi.org/10.1016/j.cell.2017.01.018
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, CELL LUNG-CANCER, POTENTIAL THERAPEUTIC TARGETS, CHRONIC LYMPHOCYTIC-LEUKEMIA, METASTATIC PROSTATE-CANCER, PAIRED EXOME ANALYSIS, BREAST-CANCER, ESOPHAGEAL ADENOCARCINOMA, MUTATIONAL PROCESSES, COLORECTAL-CANCER, COPY NUMBER
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10046495
Downloads since deposit
329Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item