UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Advances in systemic lupus erythematosus

Yeoh, SA; Dias, SS; Isenberg, DA; (2018) Advances in systemic lupus erythematosus. Medicine , 46 (2) pp. 84-92. 10.1016/j.mpmed.2017.11.010. Green open access

[thumbnail of Isenberg Advances in SLE.pdf]
Preview
Text
Isenberg Advances in SLE.pdf - Accepted Version

Download (976kB) | Preview

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a heterogeneous course and systemic involvement. It is the result of a complex pathogenic pathway that culminates in autoantibody formation. The interaction between environmental triggers and genetic susceptibility is key in this process. Genome-wide association study technology has allowed the recognition of > 80 loci associated with SLE that lead to the formation of key proteins, each contributing a small increase to the risk. Advances in the management of the disease include new validated standardized tools to capture disease activity, damage and quality of life, for clinical and research purposes. The prognosis of SLE has much improved in the last 50 years because of better general management and specific treatment, including better use of immunosuppressive agents and development of a new group of drugs – biological therapies.

Type: Article
Title: Advances in systemic lupus erythematosus
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mpmed.2017.11.010
Publisher version: https://doi.org/10.1016/j.mpmed.2017.11.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Disease activity index, management, MRCP, pathogenesis, systemic lupus erythematosus, treatment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10046462
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item