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Commentary: Whither the epigenetics of child psychopathology? Some reflections provoked by Barker et al. (2018)

Sonuga-Barke, EJS; Fearon, P; (2018) Commentary: Whither the epigenetics of child psychopathology? Some reflections provoked by Barker et al. (2018). Journal of Child Psychology and Psychiatry , 59 (4) pp. 323-326. 10.1111/jcpp.12906. Green open access

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Abstract

Barker et al.'s. (2018) review addresses one of the most fundamental questions in the fields of child psychology and psychiatry - How can adverse experiences shape development to a sufficient degree and in profound and enduring ways to create long term risk for later mental disorder and disability? In particular they discuss the plausibility of differential methylation as an epigenetic mechanism by which such exposures can become neuro-biologically embedded. Our commentary rises six question relating to key issues that need to be addressed as we search for definitive evidence from human studies that such mechanisms actually do make an important causal contribution to abnormal trajectories of development to disorder.

Type: Article
Title: Commentary: Whither the epigenetics of child psychopathology? Some reflections provoked by Barker et al. (2018)
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jcpp.12906
Publisher version: https://doi.org/10.1111/jcpp.12906
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Epigenetics
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10046435
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