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Systemic Inflammation after Third Molar Removal: A Case-Control Study

Graziani, F; D'Aiuto, F; Gennai, S; Petrini, M; Nisi, M; Cirigliano, N; Landini, L; ... Ghiadoni, L; + view all (2017) Systemic Inflammation after Third Molar Removal: A Case-Control Study. Journal of Dental Research , 96 (13) pp. 1505-1512. 10.1177/0022034517722775. Green open access

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Abstract

Third molar extraction is one of the most frequent interventions in dentistry. Nevertheless, there is scarce evidence on the host response of individuals with impacted or semi-impacted third molars and the possible effects of surgical removal. A case-control study of 40 patients was designed to evaluate 1) the differences in biomarkers of systemic inflammation, vascular function, and metabolism (high-sensitive C-reactive protein, lipids, fibrinogen, oxidative stress, and endothelial function analysis) and 2) the acute and short-term effects of surgical removal in patients with bilateral impacted or semi-impacted third molars compared to controls with no third molars. Patients undergoing third molar extraction exhibited greater levels of systemic inflammation, oxidative stress, and triglycerides than controls. Raised white blood cell counts as well as peaks of serum levels of C-reactive protein and fibrinogen were noticed in the first postoperative week. Three months after the extraction, all markers returned to baseline values. Malondialdehyde, an indicator of oxidative stress indicator, was significantly reduced after third molar removal. Semi-impacted or impacted third molars are associated with higher systemic inflammation, and their removal may represent a useful human model to study acute inflammation and determine beneficial systemic effects ( ClinicalTrials.gov NCT03048175).

Type: Article
Title: Systemic Inflammation after Third Molar Removal: A Case-Control Study
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0022034517722775
Publisher version: https://doi.org/10.1177/0022034517722775
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: wisdom tooth, C-reactive protein, endothelium, oxidative stress, inflammation mediators, oral surgical procedures
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10046432
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