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Fabricating 3D printed orally disintegrating printlets using selective laser sintering

Fina, F; Madla, CM; Goyanes, A; Zhang, J; Gaisford, S; Basit, AW; (2018) Fabricating 3D printed orally disintegrating printlets using selective laser sintering. International Journal of Pharmaceutics , 541 (1-2) pp. 101-107. 10.1016/j.ijpharm.2018.02.015. Green open access

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Abstract

Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of using SLS to fabricate novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon®VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin®Gold Sheen colorant; the powder mixes were subjected to SLS printing, resulting in the manufacture of printlets (3DP tablets). Modulating the SLS printing parameters altered the release characteristics of the printlets, with faster laser scanning speeds accelerating drug release from the HPMC formulations. The same trend was observed for the Kollidon®based printlets. At a laser scanning speed of 300 mm/s, the Kollidon®printlets exhibited orally disintegrating characteristics by completely dispersing in <4 s in a small volume of water. X-ray micro-CT analysis of these printlets indicated a reduction in their density and an increase in open porosity, therefore, confirming the unique disintegration behaviour of these formulations. The work reported here is the first to demonstrate the feasibility of SLS 3DP to fabricate printlets with accelerated drug release and orally disintegrating properties. This investigation has confirmed that SLS is amenable to the pharmaceutical research of modern medicine manufacture.

Type: Article
Title: Fabricating 3D printed orally disintegrating printlets using selective laser sintering
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2018.02.015
Publisher version: https://doi.org/10.1016/j.ijpharm.2018.02.015
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Additive manufacturing, Orally disintegrating tablets, Personalised medicines, Rapid prototyping, Three-dimensional printing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10046369
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