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Proton Beam Therapy – the Challenges of Delivering High-quality Evidence of Clinical Benefit

Amos, R; Bulbeck, H; Burnet, N; Crellin, A; Eaton, D; Evans, P; Hall, E; ... Sharma, RA; + view all (2018) Proton Beam Therapy – the Challenges of Delivering High-quality Evidence of Clinical Benefit. Clinical Oncology , 30 (5) 10.1016/j.clon.2018.02.031. Green open access

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Abstract

The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.

Type: Article
Title: Proton Beam Therapy – the Challenges of Delivering High-quality Evidence of Clinical Benefit
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clon.2018.02.031
Publisher version: http://dx.doi.org/10.1016/j.clon.2018.02.031
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Proton beam therapy, external beam radiotherapy, clinical trials
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10046190
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