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Building ER-PM contacts: keeping calm and ready on alarm

Stefan, CJ; (2018) Building ER-PM contacts: keeping calm and ready on alarm. Current Opinion in Cell Biology , 53 pp. 1-8. 10.1016/j.ceb.2018.03.008. Green open access

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Abstract

It is well over half a century since contacts between organelles such as the endoplasmic reticulum (ER), mitochondria, and the plasma membrane (PM) were first observed in electron microscopy studies. Still, these early images of seemingly rare organelle interactions continue to capture the attention and curiosity of cell biologists even today. From seminal studies first proposing roles for organelle cross talk in excitable cells, the field has now expanded to cover nearly all aspects of eukaryotic cell biology, from calcium and membrane lipid transport to vesicular trafficking, cell signaling, metabolism, and homeostasis. This review highlights recent discoveries pointing to vital roles for ER-PM contacts in membrane lipid dynamics and organization.

Type: Article
Title: Building ER-PM contacts: keeping calm and ready on alarm
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceb.2018.03.008
Publisher version: https://doi.org/10.1016/j.ceb.2018.03.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10046083
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