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Emerging molecular targets and therapy for cholangiocarcinoma

Kayhanian, H; Smyth, EC; Braconi, C; (2017) Emerging molecular targets and therapy for cholangiocarcinoma. [Review]. World Journal of Gastrointestinal Oncology , 9 (7) pp. 268-280. 10.4251/wjgo.v9.i7.268. Green open access

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Abstract

Cholangiocarcinoma (CCA) is a clinically challenging malignancy; it is rare, molecularly heterogenous and associated with a poor prognosis. Here we review recent data on the genomic landscape of CCA and highlight the results of clinical trials using targeted agents and immunotherapy. We find a number of promising therapeutic agents in development and discuss strategies to improve diagnosis and outcomes in this patient group.

Type: Article
Title: Emerging molecular targets and therapy for cholangiocarcinoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.4251/wjgo.v9.i7.268
Publisher version: http://doi.org/10.4251/wjgo.v9.i7.268
Language: English
Additional information: opyright © Authors 2017. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/
Keywords: Cholangiocarcinoma; biliary tract cancer; targeted therapy; immunotherapy; mutation; molecular; microenvironment; stroma; MiRNA
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/10045858
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