Kayhanian, H;
Smyth, EC;
Braconi, C;
(2017)
Emerging molecular targets and therapy for cholangiocarcinoma.
[Review].
World Journal of Gastrointestinal Oncology
, 9
(7)
pp. 268-280.
10.4251/wjgo.v9.i7.268.
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Abstract
Cholangiocarcinoma (CCA) is a clinically challenging malignancy; it is rare, molecularly heterogenous and associated with a poor prognosis. Here we review recent data on the genomic landscape of CCA and highlight the results of clinical trials using targeted agents and immunotherapy. We find a number of promising therapeutic agents in development and discuss strategies to improve diagnosis and outcomes in this patient group.
| Type: | Article |
|---|---|
| Title: | Emerging molecular targets and therapy for cholangiocarcinoma |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4251/wjgo.v9.i7.268 |
| Publisher version: | http://doi.org/10.4251/wjgo.v9.i7.268 |
| Language: | English |
| Additional information: | opyright © Authors 2017. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/ |
| Keywords: | Cholangiocarcinoma; biliary tract cancer; targeted therapy; immunotherapy; mutation; molecular; microenvironment; stroma; MiRNA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10045858 |
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