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Tapering Analysis of Airways with Bronchiectasis

Quan, K; Shipley, R; Tanno, R; McPhillips, G; Vavourakis, V; Edwards, D; Jacob, J; ... Hawkes, D; + view all (2018) Tapering Analysis of Airways with Bronchiectasis. In: Proceedings of SPIE 10574, Medical Imaging 2018: Image Processing, 105742G. SPIE: Texas, USA. (In press). Green open access

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Abstract

Bronchiectasis is the permanent dilation of airways. Patients with the disease can suffer recurrent exacerbations, reducing their quality of life. The gold standard to diagnose and monitor bronchiectasis is accomplished by inspection of chest computed tomography (CT) scans. A clinician examines the broncho-arterial ratio to determine if an airway is brochiectatic. The visual analysis assumes the blood vessel diameter remains constant, although this assumption is disputed in the literature. We propose a simple measurement of tapering along the airways to diagnose and monitor bronchiectasis. To this end, we constructed a pipeline to measure the cross-sectional area along the airways at contiguous intervals, starting from the carina to the most distal point observable. Using a phantom with calibrated 3D printed structures, the precision and accuracy of our algorithm extends to the sub voxel level. The tapering measurement is robust to bifurcations along the airway and was applied to chest CT images acquired in clinical practice. The result is a statistical difference in tapering rate between airways with bronchiectasis and controls.

Type: Proceedings paper
Title: Tapering Analysis of Airways with Bronchiectasis
Event: SPIE 10574, Medical Imaging 2018: Image Processing, 105742G
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2292306
Publisher version: http://doi.org/10.1117/12.2292306
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Chest Computed Tomography, Pulmonary Vessels, Image Analysis, Lung, 3D Printing, Bifurcations.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10045622
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