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Cell-Intrinsic Control of Intemeuron Migration Drives Cortical Morphogenesis

Silva, CG; Peyre, E; Adhikari, MH; Tielens, S; Tanco, S; Van Damme, P; Magno, L; ... Nguyen, L; + view all (2018) Cell-Intrinsic Control of Intemeuron Migration Drives Cortical Morphogenesis. Cell , 172 (5) 1063-1078.e19. 10.1016/j.cell.2018.01.031. Green open access

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Abstract

Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers.

Type: Article
Title: Cell-Intrinsic Control of Intemeuron Migration Drives Cortical Morphogenesis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2018.01.031
Publisher version: http://dx.doi.org/10.1016/j.cell.2018.01.031
Additional information: © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: KINASE RHO-KINASE, GABAERGIC INTERNEURONS, MYOSIN PHOSPHATASE, NEURON NUMBER, CORTEX, PROTEIN, AUTISM, POLYGLUTAMYLATION, CARBOXYPEPTIDASES, PHOSPHORYLATION,neurogenesis, glutamylation, carboxypeptidase, corticogenesis, actomyosin, cytoskeleton, MLCK
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10045478
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