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Liver cell therapy: is this the end of the beginning?

Alwahsh, SM; Rashidi, H; Hay, DC; (2018) Liver cell therapy: is this the end of the beginning? Cellular and Molecular Life Sciences , 75 (8) pp. 1307-1324. 10.1007/s00018-017-2713-8. Green open access

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Abstract

The prevalence of liver diseases is increasing globally. Orthotopic liver transplantation is widely used to treat liver disease upon organ failure. The complexity of this procedure and finite numbers of healthy organ donors have prompted research into alternative therapeutic options to treat liver disease. This includes the transplantation of liver cells to promote regeneration. While successful, the routine supply of good quality human liver cells is limited. Therefore, renewable and scalable sources of these cells are sought. Liver progenitor and pluripotent stem cells offer potential cell sources that could be used clinically. This review discusses recent approaches in liver cell transplantation and requirements to improve the process, with the ultimate goal being efficient organ regeneration. We also discuss the potential off-target effects of cell-based therapies, and the advantages and drawbacks of current pre-clinical animal models used to study organ senescence, repopulation and regeneration.

Type: Article
Title: Liver cell therapy: is this the end of the beginning?
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00018-017-2713-8
Publisher version: http://doi.org/10.1007/s00018-017-2713-8
Language: English
Additional information: Copyright © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Hepatocyte-like cells (HLCs), Co-culture, Cell tracking, Mesenchymal stem cells (MSCs), Cell sheet, Biomaterials, Extracellular matrix, Hepatic progenitor cells, Engraftment, Diferentiation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10045388
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