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Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer

Loveday, C; Litchfield, K; Levy, M; Holroyd, A; Broderick, P; Kote-Jarai, Z; Dunning, AM; ... Turnbull, C; + view all (2018) Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. Oncotarget , 9 (16) pp. 12630-12638. 10.18632/oncotarget.23117. Green open access

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Abstract

Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci influencing TGCT risk. To further evaluate the association of recently proposed risk SNPs with TGCT at 2q14.2, 3q26.2, 7q36.3, 10q26.13 and 15q21.3, we analyzed genotype data on 3,206 cases and 7,422 controls. Our analysis provides independent replication of the associations for risk SNPs at 2q14.2 (rs2713206 at P = 3.03 x 10 -2 ; P-meta = 3.92 x 10-8; nearest gene, TFCP2L1) and rs12912292 at 15q21.3 (P = 7.96 x 10 -11 ; P-meta = 1.55 x 10 -19 ; nearest gene PRTG). Case-only analyses did not reveal specific associations with TGCT histology. TFCP2L1 joins the growing list of genes located within TGCT risk loci with biologically plausible roles in developmental transcriptional regulation, further highlighting the importance of this phenomenon in TGCT oncogenesis.

Type: Article
Title: Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.18632/oncotarget.23117
Publisher version: https://doi.org/10.18632/oncotarget.23117
Language: English
Additional information: Copyright: Loveday et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0) (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: testicular cancer; germ cell tumor; TGCT; GWAS; oncoarray
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research
URI: https://discovery.ucl.ac.uk/id/eprint/10045373
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