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Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors

Weheliye, HW; Cagney, N; Rodriguez, G; Micheletti, M; Ducci, A; (2018) Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors. Physics of Fluids , 30 , Article 033603. 10.1063/1.5016305. Green open access

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Abstract

In this study, two mode decomposition techniques were applied and compared to assess the flow dynamics in an orbital shaken bioreactor (OSB) of cylindrical geometry and flat bottom: proper orthogonal decomposition and dynamic mode decomposition. Particle Image Velocimetry (PIV) experiments were carried out for different operating conditions including fluid height, h, and shaker rotational speed, N. A detailed flow analysis is provided for conditions when the fluid and vessel motions are in-phase (Fr = 0.23) and out-of-phase (Fr = 0.47). PIV measurements in vertical and horizontal planes were combined to reconstruct low order models of the full 3D flow and to determine its Finite-Time Lyapunov Exponent (FTLE) within OSBs. The combined results from the mode decomposition and the FTLE fields provide a useful insight into the flow dynamics and Lagrangian coherent structures in OSBs and offer a valuable tool to optimise bioprocess design in terms of mixing and cell suspension. Published by AIP Publishing. https://doi.org/10.1063/1.5016305

Type: Article
Title: Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1063/1.5016305
Publisher version: http://doi.org/10.1063/1.5016305
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10045261
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