Weheliye, HW;
Cagney, N;
Rodriguez, G;
Micheletti, M;
Ducci, A;
(2018)
Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors.
Physics of Fluids
, 30
, Article 033603. 10.1063/1.5016305.
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Abstract
In this study, two mode decomposition techniques were applied and compared to assess the flow dynamics in an orbital shaken bioreactor (OSB) of cylindrical geometry and flat bottom: proper orthogonal decomposition and dynamic mode decomposition. Particle Image Velocimetry (PIV) experiments were carried out for different operating conditions including fluid height, h, and shaker rotational speed, N. A detailed flow analysis is provided for conditions when the fluid and vessel motions are in-phase (Fr = 0.23) and out-of-phase (Fr = 0.47). PIV measurements in vertical and horizontal planes were combined to reconstruct low order models of the full 3D flow and to determine its Finite-Time Lyapunov Exponent (FTLE) within OSBs. The combined results from the mode decomposition and the FTLE fields provide a useful insight into the flow dynamics and Lagrangian coherent structures in OSBs and offer a valuable tool to optimise bioprocess design in terms of mixing and cell suspension. Published by AIP Publishing. https://doi.org/10.1063/1.5016305
| Type: | Article |
|---|---|
| Title: | Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1063/1.5016305 |
| Publisher version: | http://doi.org/10.1063/1.5016305 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10045261 |
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