UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Are we seeing any better? A comprehensive comparison of myelin biomarkers in the healthy and multiple sclerosis post mortem spinal cord

Battiston, M; Schneider, T; Grussu, F; Schenk, GJ; Wergeland, S; Tachrount, M; Yiannakas, M; ... Samson, R; + view all (2018) Are we seeing any better? A comprehensive comparison of myelin biomarkers in the healthy and multiple sclerosis post mortem spinal cord. In: Proceedings of the Joint Annual Meeting ISMRM-ESMRMB 2018. ISMRM: Paris, France. Green open access

[thumbnail of Battiston_exvivo_spinalcord.pdf]
Preview
Text
Battiston_exvivo_spinalcord.pdf - Accepted Version

Download (1MB) | Preview

Abstract

Conventional MRI of the multiple sclerosis (MS) spinal cord offers low specificity to underlying pathological processes taking place. Quantitative MRI metrics able to characterize damage at the microstructural level are required. Of particular interest are those known to be sensitive to myelin content, which can be generated via various different contrast mechanisms. It is important to assess the specificity of such prospective myelin biomarkers to MS spinal cord pathology and validation studies comparing MRI with histological findings are essential for this purpose. Here a comparison of myelinsensitive quantitative MRI metrics measured in MS and healthy ex vivo cord are presented.

Type: Proceedings paper
Title: Are we seeing any better? A comprehensive comparison of myelin biomarkers in the healthy and multiple sclerosis post mortem spinal cord
Event: Joint Annual Meeting ISMRM-ESMRMB 2018
Location: Paris
Dates: 15 June 2018 - 18 June 2018
Open access status: An open access version is available from UCL Discovery
Publisher version: https://www.ismrm.org/18/program_files/O13.htm
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10045177
Downloads since deposit
29Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item