Seghier, ML;
Price, CJ;
(2018)
Interpreting and Utilising Intersubject Variability in Brain Function.
Trends in Cognitive Sciences
, 22
(6)
pp. 517-530.
10.1016/j.tics.2018.03.003.
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Abstract
We consider between-subject variance in brain function as data rather than noise. We describe variability as a natural output of a noisy plastic system (the brain) where each subject embodies a particular parameterisation of that system. In this context, variability becomes an opportunity to: (i) better characterise typical versus atypical brain functions; (ii) reveal the different cognitive strategies and processing networks that can sustain similar tasks; and (iii) predict recovery capacity after brain damage by taking into account both damaged and spared processing pathways. This has many ramifications for understanding individual learning preferences and explaining the wide differences in human abilities and disabilities. Understanding variability boosts the translational potential of neuroimaging findings, in particular in clinical and educational neuroscience.
| Type: | Article |
|---|---|
| Title: | Interpreting and Utilising Intersubject Variability in Brain Function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tics.2018.03.003 |
| Publisher version: | https://doi.org/10.1016/j.tics.2018.03.003 |
| Language: | English |
| Additional information: | Copyright © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | neuroimaging, functional variability, brain structure, cognitive strategies, individualised predictions, covariance |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10045160 |
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