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Pattern Onset ERGs and VEPs Produced by Patterns Arising From Light Increment and Decrement

Fritsch, DM; Sowden, JC; Thompson, DA; (2018) Pattern Onset ERGs and VEPs Produced by Patterns Arising From Light Increment and Decrement. Investigative Ophthalmology & Visual Science , 59 (1) pp. 94-99. 10.1167/iovs.17-22984. Green open access

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Abstract

PURPOSE: Our aim was to elaborate how on and off signals contribute to pattern ERGs and pattern visual evoked potentials (VEPs) by using pedestal patterns arising from incremental and decremental onset stimulation. METHODS: Pattern onset/offset ERGs and VEPs were produced by black and white checks of 60' side length and 88% spatial contrast appearing in a 16° field for 200 ms from white (110 cd/m2), black (7 cd/m2), and gray (48 cd/m2) backgrounds and disappeared for 1000 ms. Twenty healthy subjects participated in the study (median age 19.5, range, 5-31 years), 10 of whom also underwent pattern onset/offset ERG recordings to the same stimuli (median age 25.7, range, 22-31 years). VEPs were recorded from an occipital array referred to Fz. Pattern electroretinograms (PERGs) were recorded from "Dawson-Trick-Litzkow" (DTL) plus corneal electrodes referred to ipsilateral outer canthi. RESULTS: There was high correlation within subjects of the VEP waveform produced by patterns arising from light increment and decrement (group mean correlation coefficient of PVEPs to check appearance from black versus white: 87%). An average of increment and decrement PERGs simulated the onset PERG from a gray background. This waveform is akin to standard International Society for Clinical Electrophysiology of Vision (ISCEV) clinical PERGs to reversing checks. CONCLUSIONS: In healthy individuals, the early components of the pattern onset/offset VEP waveforms are comparable to light increment and decrement pedestal stimulation. Pattern onset/offset ERGs to pedestal stimulation may be used to probe simultaneous recording of ERGs with VEPs in order to obtain an assessment of retinal ganglion cell and optic pathway function in patients with less stable fixation.

Type: Article
Title: Pattern Onset ERGs and VEPs Produced by Patterns Arising From Light Increment and Decrement
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/iovs.17-22984
Publisher version: http://doi.org/10.1167/iovs.17-22984
Language: English
Additional information: Copyright 2018 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords: ON-pathway, VEP, PERG, congenital nystagmus, OFF-pathway
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10045029
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