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Cytochrome c Oxidase: Insight into Functions from Studies of the Yeast S. cerevisiae Homologue

Rich, PR; (2017) Cytochrome c Oxidase: Insight into Functions from Studies of the Yeast S. cerevisiae Homologue. In: Barber, J and Ruban, AV, (eds.) Photosynthesis and Bioenergetics. (pp. 65-80). World Scientific Publishing: Singapore. Green open access

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Abstract

Different members of the superfamily of haem-copper oxidases have diverse substrates, cofactors and protein subunits. Nevertheless, all appear to catalyse oxygen reduction with a structurally-similar catalytic binuclear centre. This is housed in a common subunit I together with a low spin haem electron donor to the catalytic centre. All also appear to be coupled to additional proton translocation. However, the possible pathways for movement of protons through the protein structures are not universally conserved. Hence, although the basic mechanism of coupling is likely to follow similar principles, the detailed atomic mechanisms are likely to be different between the A and the B/C subgroups, and have even been suggested to differ between vertebrate mitochondrial cytochrome c oxidases and bacterial quinol and cytochrome c oxidases within the same A1 subgroup. Here, studies of the yeast mitochondrial homologue are reviewed that shed light on roles of different possible proton transfer pathways and some of the additional subunits found in mitochondrial enzymes.

Type: Book chapter
Title: Cytochrome c Oxidase: Insight into Functions from Studies of the Yeast S. cerevisiae Homologue
ISBN-13: 9789813230293
Open access status: An open access version is available from UCL Discovery
DOI: 10.1142/9789813230309_0004
Publisher version: https://doi.org/10.1142/9789813230309_0004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10045018
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