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Management of child MDR-TB contacts across countries in the WHO European Region: A survey of current practice

Turkova, A; Tebruegge, M; Brinkmann, F; Tsolia, M; Mouchet, F; Kampmann, B; Seddon, JA; (2017) Management of child MDR-TB contacts across countries in the WHO European Region: A survey of current practice. International Journal of Tuberculosis and Lung Disease , 21 (7) pp. 774-777. 10.5588/ijtld.16.0949. Green open access

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Abstract

The World Health Organization European Region has one of the highest rates of multidrug-resistant tuberculosis (MDR-TB) in the world, resulting in many vulnerable children being exposed each year. Evidence for preventive therapy following MDR-TB exposure is limited and current guidance is conflicting. An internetbased survey was performed to determine clinical practice in this region. Seventy-Two clinicians from 25 countries participated. Practices related to screening and decision-making were highly variable. Just over half provided preventive therapy for children exposed to MDR-TB; the only characteristic associated with provision was practice within the European Union (adjusted OR 4.07, 95%CI 1.33-12.5).

Type: Article
Title: Management of child MDR-TB contacts across countries in the WHO European Region: A survey of current practice
Open access status: An open access version is available from UCL Discovery
DOI: 10.5588/ijtld.16.0949
Publisher version: https://doi.org/10.5588/ijtld.16.0949
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: MDR-TB; chemoprophylaxis; paediatric; preventive treatment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/10044977
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