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Zebrafish as a model for kidney function and disease

Outtandy, P; Russell, C; Kleta, R; Bockenhauer, D; (2018) Zebrafish as a model for kidney function and disease. Pediatric Nephrology 10.1007/s00467-018-3921-7. (In press). Green open access

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Abstract

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease.

Type: Article
Title: Zebrafish as a model for kidney function and disease
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00467-018-3921-7
Publisher version: http://doi.org/10.1007/s00467-018-3921-7
Language: English
Additional information: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Acute kidney injury, Animal model, Chronic kidney disease, Kidney, Polycystic kidney disease, Renal diseases, Zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10044964
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