Fullerton, JN; Thompson, K; Shetty, A; Iredell, JR; Lander, H; Myburgh, JA; Finfer, S; (2017) New sepsis definition changes incidence of sepsis in the intensive care unit. Critical Care and Resuscitation , 19 (1) pp. 9-13.

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Abstract

Sepsis lacks pathognomonic clinical features and a definitive biochemical or histological diagnostic test. As a result, since 1992, diagnosis of sepsis has been based on the presence of two or more of the criteria characterising the systemic inflammatory response syndrome (SIRS) (Table 1) arising from suspected or proven infection. In response to data questioning this construct, new criteria redefining sepsis, based on the Sequential Organ Failure Assessment (SOFA) score, have been proposed: Sepsis-3 (Table 1). The epidemiological and clinical implications of adopting these new criteria are currently unknown. We aimed to estimate the impact of adopting SOFA-based diagnostic criteria for sepsis on the diagnosis and apparent mortality of sepsis in Australian and New Zealand intensive care units.

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