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Biological Control of Appetite: A Daunting Complexity

MacLean, PS; Blundell, JE; Mennella, JA; Batterham, RL; (2017) Biological Control of Appetite: A Daunting Complexity. Obesity , 25 (S1) S8-S16. 10.1002/oby.21771. Green open access

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Abstract

Objective: This review summarizes a portion of the discussions of an NIH Workshop (Bethesda, MD, 2015) titled “Self-Regulation of Appetite—It's Complicated,” which focused on the biological aspects of appetite regulation. Methods: This review summarizes the key biological inputs of appetite regulation and their implications for body weight regulation. Results: These discussions offer an update of the long-held, rigid perspective of an “adipocentric” biological control, taking a broader view that also includes important inputs from the digestive tract, from lean mass, and from the chemical sensory systems underlying taste and smell. It is only beginning to be understood how these biological systems are integrated and how this integrated input influences appetite and food eating behaviors. The relevance of these biological inputs was discussed primarily in the context of obesity and the problem of weight regain, touching on topics related to the biological predisposition for obesity and the impact that obesity treatments (dieting, exercise, bariatric surgery, etc.) might have on appetite and weight loss maintenance. Finally considered is a common theme that pervaded the workshop discussions, which was individual variability. Conclusions: It is this individual variability in the predisposition for obesity and in the biological response to weight loss that makes the biological component of appetite regulation so complicated. When this individual biological variability is placed in the context of the diverse environmental and behavioral pressures that also influence food eating behaviors, it is easy to appreciate the daunting complexities that arise with the self-regulation of appetite.

Type: Article
Title: Biological Control of Appetite: A Daunting Complexity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/oby.21771
Publisher version: http://doi.org/10.1002/oby.21771
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10044921
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