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Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 18. Physicochemical properties and photochemical behavior of new uncharged water soluble low-symmetry macrocycles [{Pd(OAc)2}3{Pd(OAc)2}3(PtCl2)LM] (M = MgII(H2O), ZNII, PdII)

Donzello, MP; Gigante, F; Sciscione, F; Viola, E; Kadish, KM; (2017) Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 18. Physicochemical properties and photochemical behavior of new uncharged water soluble low-symmetry macrocycles [{Pd(OAc)2}3{Pd(OAc)2}3(PtCl2)LM] (M = MgII(H2O), ZNII, PdII). Journal of Porphyrins and Phthalocyanines , 21 (4-6) pp. 334-344. 10.1142/S1088424617500250. Green open access

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Abstract

The synthesis and physicochemical characterization of a new class of low symmetry water soluble heteropentanuclear porphyrazine complexes are described. The investigated compounds, represented as [{Pd(OAc)2)}3(PtCl2)LM]·xH2O where L = tetrakis-2,3-[5,6-di(2-pyridyl)pyrazino]porphyrazinato dianion, M = MgII(H2O), ZnII or PdII and x = 3-8, were prepared under mild experimental conditions from the previously described heterobimetallic compounds [(PtCl2)LM]. Peripheral binding of one PtCl2 and three Pd(OAc)2 units in the new series of compounds occurs at the vicinal pyridine N atoms of each dipyridinopyrazine fragment via a “py–py” coordination. The newly synthesized porphyrazines were characterized by IR measurements in the solid state and UV-visible absorption spectroscopy in the low-donor nonaqueous solvents pyridine, dimethyl sulfoxide and dimethylformamide as well as in water, the enhanced solubility in this medium being due to the presence of the external Pd(OAc)2 moieties. Data on the photosensitizing activity of the compounds for the generation of singlet oxygen, 1O2, were also obtained in DMF and should be of interest to researchers in the area of photodynamic therapy.

Type: Article
Title: Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 18. Physicochemical properties and photochemical behavior of new uncharged water soluble low-symmetry macrocycles [{Pd(OAc)2}3{Pd(OAc)2}3(PtCl2)LM] (M = MgII(H2O), ZNII, PdII)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1142/S1088424617500250
Publisher version: http://dx.doi.org/10.1142/S1088424617500250
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Tetrapyrazinoporphyrazines, uncharged low-symmentry water soluble heteropentanuclear complexes, UV-visible spectra, photoactivity for singlet oxygen generation, Singlet Oxygen Production, Photodynamic Therapy, Substituted Phthalocyanines, Peripheral Substituents, Anticancer Agents, Quantum Yields, CU-II, CD-II, Complexes, Photosensitizers
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10044848
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