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Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

Favuzzi, E; Marques-Smith, A; Deogracias, R; Winterflood, CM; Sanchez-Aguilera, A; Mantoan, L; Maeso, P; ... Rico, B; + view all (2017) Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron , 95 (3) pp. 639-655. 10.1016/j.neuron.2017.06.028. Green open access

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Abstract

Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.

Type: Article
Title: Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2017.06.028
Publisher version: http://doi.org/10.1016/j.neuron.2017.06.028
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Parvalbumin interneurons, inhibitory circuitries, perineuronal netssynapse maturation, AMPA receptors, Kv channels, learning and memory, plasticity, activity-dependent
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/10044837
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