Favuzzi, E;
Marques-Smith, A;
Deogracias, R;
Winterflood, CM;
Sanchez-Aguilera, A;
Mantoan, L;
Maeso, P;
... Rico, B; + view all
(2017)
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Neuron
, 95
(3)
pp. 639-655.
10.1016/j.neuron.2017.06.028.
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Abstract
Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.
| Type: | Article |
|---|---|
| Title: | Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2017.06.028 |
| Publisher version: | http://doi.org/10.1016/j.neuron.2017.06.028 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Parvalbumin interneurons, inhibitory circuitries, perineuronal netssynapse maturation, AMPA receptors, Kv channels, learning and memory, plasticity, activity-dependent |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044837 |
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