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Current and future antenatal management of isolated congenital diaphragmatic hernia

Russo, FM; De Coppi, P; Allegaert, K; Toelen, J; van der Veeken, L; Attilakos, G; Eastwood, MP; ... Deprest, J; + view all (2017) Current and future antenatal management of isolated congenital diaphragmatic hernia. Seminars in Fetal and Neonatal Medicine , 22 (6) pp. 383-390. 10.1016/j.siny.2017.11.002. Green open access

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Abstract

Congenital diaphragmatic hernia is surgically correctable, yet the poor lung development determines mortality and morbidity. In isolated cases the outcome may be predicted prenatally by medical imaging. Cases with a poor prognosis could be treated before birth. However, prenatal modulation of lung development remains experimental. Fetoscopic endoluminal tracheal occlusion triggers lung growth and is currently being evaluated in a global clinical trial. Prenatal transplacental sildenafil administration may in due course be a therapeutic approach, reducing the occurrence of persistent pulmonary hypertension, either alone or in combination with fetal surgery.

Type: Article
Title: Current and future antenatal management of isolated congenital diaphragmatic hernia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.siny.2017.11.002
Publisher version: https://doi.org/10.1016/j.siny.2017.11.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: congenital diaphragmatic hernia, prenatal therapy, pulmonary hypoplasia, pulmonary hypertension, sildenafil
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10044767
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