Russo, FM;
De Coppi, P;
Allegaert, K;
Toelen, J;
van der Veeken, L;
Attilakos, G;
Eastwood, MP;
... Deprest, J; + view all
(2017)
Current and future antenatal management of isolated congenital diaphragmatic hernia.
Seminars in Fetal and Neonatal Medicine
, 22
(6)
pp. 383-390.
10.1016/j.siny.2017.11.002.
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Abstract
Congenital diaphragmatic hernia is surgically correctable, yet the poor lung development determines mortality and morbidity. In isolated cases the outcome may be predicted prenatally by medical imaging. Cases with a poor prognosis could be treated before birth. However, prenatal modulation of lung development remains experimental. Fetoscopic endoluminal tracheal occlusion triggers lung growth and is currently being evaluated in a global clinical trial. Prenatal transplacental sildenafil administration may in due course be a therapeutic approach, reducing the occurrence of persistent pulmonary hypertension, either alone or in combination with fetal surgery.
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