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Use of plasma human herpesvirus-8 viral load measurement: evaluation of practice in three UK HIV treatment centres

Nugent, DB; Webster, D; Mabayoje, D; Chung, E; El Bouzidi, K; O'Sullivan, A; Ainsworth, J; (2017) Use of plasma human herpesvirus-8 viral load measurement: evaluation of practice in three UK HIV treatment centres. International Journal of STD & AIDS , 28 (2) pp. 188-191. 10.1177/0956462416676031. Green open access

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Abstract

A retrospective audit of plasma human herpesvirus-8 (HHV-8) viral load testing was performed in three HIV treatment centres over 24 months. Reasons for testing (360 tests) were: symptoms of systemic inflammatory response syndrome (SIRS) (fever, lymphadenopathy and raised inflammatory markers); monitoring in known HHV-8 pathology other than Kaposi sarcoma (KS); investigation of known/suspected KS, and other/no reason. Of patients with multicentric Castleman disease (MCD), 14/16 (88%) had detectable plasma HHV-8, as did 27/45 (60%) with biopsy proven or clinically confirmed KS, and 6/19 (32%) with lymphoma. Neither of the two patients with MCD and no detectable HHV-8 had SIRS symptoms at the time of the test. There was wide variation between centres in the indications prompting HHV-8 testing, with a more conservative approach resulting in a higher proportion of positive results. Measuring plasma HHV-8 in the absence of SIRS symptoms, established HHV-8 disease monitoring, or confirmed/suspected KS is unlikely to yield detectable HHV-8 thus allowing potential cost savings.

Type: Article
Title: Use of plasma human herpesvirus-8 viral load measurement: evaluation of practice in three UK HIV treatment centres
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0956462416676031
Publisher version: http://dx.doi.org/10.1177/0956462416676031
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Immunology, Infectious Diseases, Human herpesvirus-8, Kaposi sarcoma, Castleman, polymerase chain reaction, MULTICENTRIC CASTLEMAN DISEASE, KAPOSI-SARCOMA
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10044742
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