Lang, EJ;
Apps, R;
Bengtsson, F;
Cerminara, NL;
De Zeeuw, CI;
Ebner, TJ;
Heck, DH;
... Xiao, J; + view all
(2017)
The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper.
The Cerebellum
, 16
(1)
pp. 230-252.
10.1007/s12311-016-0787-8.
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Abstract
For many decades, the predominant view in the cerebellar field has been that the olivocerebellar system’s primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse. However, it has also long been proposed that the olivocerebellar system participates directly in motor control by helping to shape ongoing motor commands being issued by the cerebellum. Evidence consistent with both hypotheses exists; however, they are often investigated as mutually exclusive alternatives. In contrast, here, we take the perspective that the olivocerebellar system can contribute to both the motor learning and motor control functions of the cerebellum and might also play a role in development. We then consider the potential problems and benefits of it having multiple functions. Moreover, we discuss how its distinctive characteristics (e.g., low firing rates, synchronization, and variable complex spike waveforms) make it more or less suitable for one or the other of these functions, and why having multiple functions makes sense from an evolutionary perspective. We did not attempt to reach a consensus on the specific role(s) the olivocerebellar system plays in different types of movements, as that will ultimately be determined experimentally; however, collectively, the various contributions highlight the flexibility of the olivocerebellar system, and thereby suggest that it has the potential to act in both the motor learning and motor control functions of the cerebellum.
| Type: | Article |
|---|---|
| Title: | The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s12311-016-0787-8 |
| Publisher version: | https://doi.org/10.1007/s12311-016-0787-8 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cerebellum, Inferior olive, Complex spike, Purkinje cell, Synchrony, Motor control, Motor learning |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044711 |
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