Taylor, PW;
Francis, KP;
(2018)
Can 3D imaging provide insights into spatial variations in bacterial infection patterns?
Future Microbiology
, 13
(8)
pp. 897-901.
10.2217/fmb-2017-0272.
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Abstract
Recently developed 3D noninvasive in vivo optical imaging is providing fresh insights into the understanding of the pathogenesis of invasive bacteria in small animal experimental models. Here, we describe the advantages of 3D diffuse light imaging tomography with integrated micro-computed tomography (DLIT-μCT) over more traditional 2D systems, in particular with regard to precise localization of infectious foci within tissues in 3D space. We highlight data from rodent studies that employ experimental infections replicating the course of naturally occurring bacterial disease, such as invasive Escherichia coli infections that arise following colonization of the GI tract in neonatal rats. It is argued that this technology will find increasing utility in the study and diagnosis of infectious disease.
| Type: | Article |
|---|---|
| Title: | Can 3D imaging provide insights into spatial variations in bacterial infection patterns? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/fmb-2017-0272 |
| Publisher version: | https://doi.org/10.2217/fmb-2017-0272 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 3D imaging, animal models of infection, bacterial infection, bioluminescence imaging, Citrobacter rodentium, computed tomography, DLIT- μCT, Escherichia coli |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10044706 |
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